解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::A wide variety of similarity indices for comparing two assemblages based on species incidence (i.e., presence/absence) data have been proposed in the literature. These indices are generally based on three simple incidence counts: the number of species shared by two assemblages and the number of species unique to each ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2005.00489.x
更新日期:2006-06-01 00:00:00
abstract::Geographic disease surveillance methods identify regions that have higher disease rates than expected. These approaches are generally applied to incident or prevalent cases of disease. In some contexts, disease-related events rather than individuals are the appropriate units of analysis for geographic surveillance. We...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2005.00503.x
更新日期:2006-06-01 00:00:00
abstract::Microarray technology allows the monitoring of expression levels of thousands of genes simultaneously. A semiparametric location and scale model is proposed to model gene expression levels for normalization and significance analysis purposes. Robust estimation based on weighted least absolute deviation regression and ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2005.00452.x
更新日期:2006-06-01 00:00:00
abstract::The objective of this article is to develop a hypothesis-testing procedure to determine whether a common source outbreak has ended. We consider the case when neither the calendar date of exposure to the pathogen nor the exact incubation period distribution is known. The hypothesis-testing procedure is based on the spa...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2005.00421.x
更新日期:2006-03-01 00:00:00
abstract::Recent developments in the Cormack-Jolly-Seber (CJS) model for analyzing capture-recapture data have focused on allowing the capture and survival rates to vary between individuals. Several methods have been developed in which capture and survival are functions of auxiliary variables that may be discrete, constant over...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2005.00399.x
更新日期:2006-03-01 00:00:00
abstract::Neuroendocrine ensembles communicate with their remote and proximal target cells via an intermittent pattern of chemical signaling. The identification of episodic releases of hormonal pulse signals constitutes a major emphasis of endocrine investigation. Estimating the number, temporal locations, secretion rate, and e...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2005.00403.x
更新日期:2006-03-01 00:00:00
abstract::We extend the Mantel-Haenszel estimating function to estimate both the intra-cluster pairwise correlation and the main effects for sparse clustered binary data. We propose both a composite likelihood approach and an estimating function approach for the analysis of such data. The proposed estimators are consistent and ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2005.00362.x
更新日期:2005-12-01 00:00:00
abstract::A recurring objective in longitudinal studies on aging and longevity has been the investigation of the relationship between age-at-death and current values of a longitudinal covariate trajectory that quantifies reproductive or other behavioral activity. We propose a novel technique for predicting age-at-death distribu...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2005.00378.x
更新日期:2005-12-01 00:00:00
abstract::We derive semiparametric methods for estimating and testing treatment effects when censored recurrent event data are available over multiple periods. These methods are based on estimating functions motivated by a working "mixed-Poisson" assumption under which conditioning can eliminate subject-specific random effects....
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2005.00357.x
更新日期:2005-09-01 00:00:00
abstract::Statistical methods for the detection of genes influencing quantitative traits with the aid of genetic markers are well developed for normally distributed, fully observed phenotypes. Many experiments are concerned with failure-time phenotypes, which have skewed distributions and which are usually subject to censoring ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2005.00346.x
更新日期:2005-09-01 00:00:00
abstract::In longitudinal studies and in clustered situations often binary and continuous response variables are observed and need to be modeled together. In a recent publication Dunson, Chen, and Harry (2003, Biometrics 59, 521-530) (DCH) propose a Bayesian approach for joint modeling of cluster size and binary and continuous ...
journal_title:Biometrics
pub_type: 评论,杂志文章
doi:10.1111/j.1541-020X.2005.00409_1.x
更新日期:2005-09-01 00:00:00
abstract::In this article, we propose a Bayesian approach to phase I/II dose-finding oncology trials by jointly modeling a binary toxicity outcome and a continuous biomarker expression outcome. We apply our method to a clinical trial of a new gene therapy for bladder cancer patients. In this trial, the biomarker expression indi...
journal_title:Biometrics
pub_type: 临床试验,杂志文章
doi:10.1111/j.1541-0420.2005.00314.x
更新日期:2005-06-01 00:00:00
abstract::Capture-recapture models were originally developed to account for encounter probabilities that are less than 1 in free-ranging animal populations. Nowadays, these models can deal with the movement of animals between different locations and are also used to study transitions between different states. However, their use...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2005.00318.x
更新日期:2005-06-01 00:00:00
abstract::When comparing follow-up measurements from two independent populations, missing records may arise due to censoring by events whose occurrence is associated with baseline covariates. In these situations, inferences based only on the completely followed observations may be biased if the follow-up measurements and the co...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2005.00332.x
更新日期:2005-06-01 00:00:00
abstract::In the evaluation of diagnostic accuracy of tests, a gold standard on the disease status is required. However, in many complex diseases, it is impossible or unethical to obtain such a gold standard. If an imperfect standard is used, the estimated accuracy of the tests would be biased. This type of bias is called imper...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2005.00324.x
更新日期:2005-06-01 00:00:00
abstract::In problems with missing or latent data, a standard approach is to first impute the unobserved data, then perform all statistical analyses on the completed dataset--corresponding to the observed data and imputed unobserved data--using standard procedures for complete-data inference. Here, we extend this approach to mo...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2005.031010.x
更新日期:2005-03-01 00:00:00
abstract::A mean residual life function is the average remaining life of a surviving subject, as it varies with time. The proportional mean residual life model was proposed by Oakes and Dasu (1990, Biometrika77, 409-410) in regression analysis to study its association with related covariates in absence of censoring. In this art...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2005.030224.x
更新日期:2005-03-01 00:00:00
abstract::In an effort to determine whether a particular treatment causes a particular outcome event, data are obtained from a database system that records events when they occur, and for such events, the system records exposure to the treatment. That is, the system records information about cases. The system provides no inform...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2005.030920.x
更新日期:2005-03-01 00:00:00
abstract::Estimates of waterfowl demographic parameters often come from resighting studies where birds fit with individually identifiable neck collars are resighted at a distance. Concerns have been raised about the effects of collar loss on parameter estimates, and the reliability of extrapolating from collared individuals to ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2004.00245.x
更新日期:2004-12-01 00:00:00
abstract::This article is motivated by a lung cancer study where a regression model is involved and the response variable is too expensive to measure but the predictor variable can be measured easily with relatively negligible cost. This situation occurs quite often in medical studies, quantitative genetics, and ecological and ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2004.00255.x
更新日期:2004-12-01 00:00:00
abstract::Gene-disease association studies based on case-control designs may often be used to identify candidate polymorphisms (markers) conferring disease risk. If a large number of markers are studied, genotyping all markers on all samples is inefficient in resource utilization. Here, we propose an alternative two-stage metho...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2004.00207.x
更新日期:2004-09-01 00:00:00
abstract::In studying rates of occurrence and progression of lesions (or tumors), it is typically not possible to obtain exact onset times for each lesion. Instead, data consist of the number of lesions that reach a detectable size between screening examinations, along with measures of the size/severity of individual lesions at...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2004.00217.x
更新日期:2004-09-01 00:00:00
abstract::We present an approach for analyzing internal dependencies in counting processes. This covers the case with repeated events on each of a number of individuals, and more generally, the situation where several processes are observed for each individual. We define dynamic covariates, i.e., covariates depending on the pas...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2004.00227.x
更新日期:2004-09-01 00:00:00
abstract::In multivariate survival analysis, investigators are often interested in testing for heterogeneity among clusters, both overall and within specific classes. We represent different hypotheses about the heterogeneity structure using a sequence of gamma frailty models, ranging from a null model with no random effects to ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2004.00179.x
更新日期:2004-06-01 00:00:00
abstract::In this article, we propose a graphical technique for assessing the goodness-of-fit of a stationary hidden Markov model (HMM). We show that plots of the estimated distribution against the empirical distribution detect lack of fit with high probability for large sample sizes. By considering plots of the univariate and ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2004.00189.x
更新日期:2004-06-01 00:00:00
abstract::We propose a likelihood-based test for comparing the means of two or more log-normal distributions, with possibly unequal variances. A modification to the likelihood ratio test is needed when sample sizes are small. The performance of the proposed procedures is compared with the F-ratio test using Monte Carlo simulati...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2004.00199.x
更新日期:2004-06-01 00:00:00
abstract::Bayesian experimental design is investigated for Bayesian analysis of nonlinear mixed-effects models. Existence of the posterior risk for parameter estimation is shown. When the same prior distribution is used for both design and inference, existence of the preposterior risk for design is also proven. If the prior dis...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2004.00148.x
更新日期:2004-03-01 00:00:00
abstract::Spatial replication is a common theme in count surveys of animals. Such surveys often generate sparse count data from which it is difficult to estimate population size while formally accounting for detection probability. In this article, I describe a class of models (N-mixture models) which allow for estimation of pop...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2004.00142.x
更新日期:2004-03-01 00:00:00
abstract::Training data in a supervised learning problem consist of the class label and its potential predictors for a set of observations. Constructing effective classifiers from training data is the goal of supervised learning. In biomedical sciences and other scientific applications, class labels may be subject to errors. We...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2004.00156.x
更新日期:2004-03-01 00:00:00
abstract::This article describes the theoretical and practical issues in experimental design for gene expression microarrays. Specifically, this article 1) discusses the basic principles of design (randomization, replication, and blocking) as they pertain to microarrays, and 2) provides some general guidelines for statisticians...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2003.00096.x
更新日期:2003-12-01 00:00:00
abstract::In studying the relationship between an ordered categorical predictor and an event time, it is standard practice to include dichotomous indicators of the different levels of the predictor in a Cox model. One can then use a multiple degree-of-freedom score or partial likelihood ratio test for hypothesis testing. Often,...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2003.00106.x
更新日期:2003-12-01 00:00:00
abstract::Suppose that the response variable in a well-executed clinical or observational study to evaluate a treatment is the time to a certain event, and a set of baseline covariates or predictors was collected for each study patient. Furthermore, suppose that a significant number of study patients had nontrivial, long-term a...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2003.00116.x
更新日期:2003-12-01 00:00:00
abstract::In this article, we study nonparametric estimation of the mean function of a counting process with panel observations. We introduce the gamma frailty variable to account for the intracorrelation between the panel counts of the counting process and construct a maximum pseudo-likelihood estimate with the frailty variabl...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2003.00126.x
更新日期:2003-12-01 00:00:00
abstract::When testing the null hypothesis that treatment arm-specific survival-time distributions are equal, the log-rank test is asymptotically valid when the distribution of time to censoring is conditionally independent of randomized treatment group given survival time. We introduce a test of the null hypothesis for use whe...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/1541-0420.00059
更新日期:2003-09-01 00:00:00
abstract::A broad approach to the design of Phase I clinical trials for the efficient estimation of the maximum tolerated dose is presented. The method is rooted in formal optimal design theory and involves the construction of constrained Bayesian c- and D-optimal designs. The imposed constraint incorporates the optimal design ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/1541-0420.00069
更新日期:2003-09-01 00:00:00
abstract::Complex issues arise when investigating the association between longitudinal immunologic measures and time to an event, such as time to relapse, in cancer vaccine trials. Unlike many clinical trials, we may encounter patients who are cured and no longer susceptible to the time-to-event endpoint. If there are cured pat...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/1541-0420.00079
更新日期:2003-09-01 00:00:00
abstract::Whenever inference for variance components is required, the choice between one-sided and two-sided tests is crucial. This choice is usually driven by whether or not negative variance components are permitted. For two-sided tests, classical inferential procedures can be followed, based on likelihood ratios, score stati...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/1541-0420.00032
更新日期:2003-06-01 00:00:00
abstract::We develop a parameterization of the beta-binomial mixture that provides sensible inferences about the size of a closed population when probabilities of capture or detection vary among individuals. Three classes of mixture models (beta-binomial, logistic-normal, and latent-class) are fitted to recaptures of snowshoe h...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/1541-0420.00042
更新日期:2003-06-01 00:00:00
abstract::In an analysis of capture-recapture data, the identification of a model that fits is a critical step. For the multisite (also called multistate) models used to analyze data gathered at several sites, no reliable test for assessing fit is currently available. We propose a test for the JMV model, a simple generalization...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/1541-0420.00006
更新日期:2003-03-01 00:00:00
abstract::High throughput technologies, such as gene expression arrays and protein mass spectrometry, allow one to simultaneously evaluate thousands of potential biomarkers that could distinguish different tissue types. Of particular interest here is distinguishing between cancerous and normal organ tissues. We consider statist...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/1541-0420.00016
更新日期:2003-03-01 00:00:00